Rewinding development: A step forward for stem cell research

Rewinding development: A step forward for stem cell research

Embryonic stem cells can make all kinds of adult cells in the human body such as muscle, blood or brain cells. However, these embryonic stem cells are created at a point when the embryo has already lost the ability to make extra-embryonic tissue such as placenta and yolk sac. Extra-embryonic tissues are formed at the very earliest stage of development right after fertilization and are essential for the growth of the embryo and its implantation in the womb.

A team of scientists at the Danish Stem Cell Center, DanStem, at the University of Copenhagen have shown that it is possible to rewind the developmental state of embryonic stem cells. By maintaining mouse embryonic stem cells under certain conditions, they found that cells appear to regress and resemble extremely early embryo cells that can form any kind of cell including placenta and yolk sac cells.

"It was a very exciting moment when we tested the theory," says Professor Josh Brickman from DanStem. "We found that not only can we make adult cells but also placenta, in fact we got precursors of placenta, yolk sac as well as embryo from just one cell."

Sophie Morgani, PhD student at DanStem and first author of the paper, which was published in the scientific journal Cell Reports todayadds: "This new discovery is crucial for the basic understanding of the nature of embryonic stem cells and could provide a way to model the development of the organism as a whole, rather than just the embryonic portion. In this way we may gain greater insight into conditions where extra-embryonic development is impaired, as in the case of miscarriages."

LIF protein plays a crucial role

Brickman and colleagues grew their embryonic stem cells in a solution containing LIF, which is a protein known to somehow support embryonic stem cells but also for its role in implantation of the embryo into the uterus. As implantation is stimulated by the cells that will become the placenta, not the embryo, these roles appeared to be contradictory. The DanStem study resolved this contradiction by revealing that LIF helps maintain the cells in their regressed, early stage of development.

"In our study we have been able to see the full picture unifying LIF's functions: What LIF really does, is to support the very early embryo state, where the cells can make both embryonic cells and placenta. This fits with LIFs' role in supporting implantation," Josh Brickman says.

Welcome to SUV System Ltd!

SUV System Ltd is ISO 90012008 Certified electronics distributor with 10 years of experiences.

We have built up long term business relationship with about many companies which are stockers and authorized agents. we have a steady and reliable supply to meet customer's demands to the greatest extent .Confidently, we are able to lower your cost and support your business with our years of professional service.

SUV System Ltd is Electronic Components Distributor Supplies,Find Quality Electronic Components Supplies Products IC(Integrated Circuits),Connectors,Capacitor,Resistors,Diodes,Transistors,LED at Suvsystem.com. Sourcing Other Energy, Environment, Excess Inventory Products from Manufacturers and Suppliers at Suvsystem.com

Electronic Components distributor:http://www.suvsystem.com

Connectors Distributor:http://www.suvsystem.com/l/Connectors-1.html

IC Distributor:http://www.suvsystem.com/l/IC(Integrated-Circuits)-1.html

LED Distributor:http://www.suvsystem.com/l/LED-1.html

Capacitor Distributor:http://www.suvsystem.com/l/Capacitor-1.html

Transistor Distributor:http://www.suvsystem.com/l/Transistors-1.html

Resistor Distributor:http://www.suvsystem.com/l/Resistors-1.html

Diode Distributor:http://www.suvsystem.com/l/Diodes-1.html

SUV System Ltd insists on the managing faith ofsincereness,speciality,foresight, win-win,so we build up stable-relationship customers located all over the world, including the States, Europe, Argentina, UAE, Malaysia, Australia,and India etc

we are focus on the following fields,and hope we can help you.

CR2512-JW-302ELF CR2512-JW-300ELF CR2512-JW-273ELF CR2512-JW-272ELF CR2512-JW-271ELF CR2512-JW-270ELF CR2512-JW-242ELF CR2512-JW-223ELF CR2512-JW-222ELF CR2512-JW-221ELF CR2512-JW-220ELF CR2512-JW-201ELF CR2512-JW-182ELF CR2512-JW-181ELF CR2512-JW-180ELF CR2512-JW-154ELF CR2512-JW-153ELF CR2512-JW-152ELF CR2512-JW-151ELF CR2512-JW-123ELF CR2512-JW-122ELF CR2512-JW-121ELF CR2512-JW-112ELF CR2512-JW-106ELF CR2512-JW-104ELF CR2512-JW-102ELF CR2512-JW-102E CR2512-JW-101ELF CR2RL-201 CR2RL-151 CR-2PA/1BOEM CR2-M CR2LS-75 CR2DARL-500 CR2DARL-301 CR2DARL-151 CR2DARL-101 CR2A10YTTE470M/470J CR2A10YTTE101M/820J CR27-601CA
http://www.suvsystem.com/a/2308.aspx